Recommendations for False Negative Covid-19 PCR Tests Patients

Invasive Aspergillosis in COVID-19: A Review Study and Recommendations for Diagnostic Approaches

Background and purpose: COVID-19 is an emerging viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Bacterial or fungal superinfections of the lung may cause complications in clinical manifestations, treatment, and increase the mortality rate. In this article, we reviewed previous studies on invasive aspergillosis (IA) in viral infections and in adjustment with...

False-negative cerebrospinal fluid cryptococcal latex agglutination tests for patients with culture-positive cryptococcal meningitis.

Three cases of false-negative cerebrospinal fluid latex agglutination test results for patients with culture-positive cryptococcal meningitis are reported. False-negative results occurred in settings of low cryptococcal antigen concentrations in cerebrospinal fluid and were dependent on the latex agglutination test kit used. Investigation of each case revealed that prozone phenomena or interfer...

COVID-19 in Nursing Homes: The Problematic Management of Residents Without Positive COVID-19 RT-PCR

Herpes Simplex Encephalitis with Two False-Negative Cerebrospinal Fluid PCR Tests and Review of Negative PCR Results in the Clinical Setting

INTRODUCTION Herpes simplex virus encephalitis (HSE) is an acute infection accompanied by significant morbidity and mortality with the diagnosis often made by cerebrospinal fluid (CSF) polymerase chain reaction (PCR) testing. CASE PRESENTATION We report a case of a healthy 35-year-old woman presenting with altered mental status. Due to suspicion of herpes encephalitis, a CSF PCR for herpes vi...

False-negative thermonuclease tests with new BacTAlert blood culture bottles.

The Microbiology Unit of Southern Cross Pathology Australia, Monash Medical Centre, has used the Organon Technika BacTAlert automated blood culture instrument since 1995 for the detection of causative organisms of septicemia and bacteremia. When a blood culture bottle is flagged as positive, it is removed from the instrument and subculturing and Gram staining are performed. Gram-positive cocci,...